http://www.neurologyproductguide.com/blog A comprehensive guide to neurology products for medical professionals Tue, 27 Jul 2010 08:29:25 +0000 http://wordpress.org/?v=2.8.2 en hourly 1 http://www.neurologyproductguide.com/blog/2009/01/02/cylene-initiates-phase-ii-clinical-trial-of-quarfloxin-cx-3543/ http://www.neurologyproductguide.com/blog/2009/01/02/cylene-initiates-phase-ii-clinical-trial-of-quarfloxin-cx-3543/#comments Fri, 02 Jan 2009 11:55:36 +0000 Jim Marino http://www.neurologyproductguide.com/blog/2009/01/02/cylene-initiates-phase-ii-clinical-trial-of-quarfloxin-cx-3543/ Cylene Pharmaceuticals has announced the initiation of a Phase II clinical trial of quarfloxin (CX-3543) in patients with carcinoid/neuroendocrine tumors (C/NET), which are malignant cancers arising from neural crest cells. Quarfloxin (CX-3543) is a small molecule that disrupts a protein:rDNA complex that forms in the abnormal nucleoli of cancer cells, thereby selectively inducing apoptotic cell death in cancers. In this open-label Phase II trial, quarfloxin will be administered to patients with low or intermediate grade C/NET, including those receiving concomitant treatment with a stable dose of octreotide.

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